Acetyl hexapeptide-8 is a synthetic peptide often found in a wide range of skincare and makeup products. You may also know it as Argireline or acetyl hexapeptide-3. Like all peptides, it has water-binding and skin-repairing properties. It works by targeting the expression of wrinkles; however, this claim is often overstated in certain cosmetics products. Although Argireline is very effective in smoothing and reducing wrinkles, it doesn't replace in-office wrinkle-smoothing injectable procedures like Botox.

Research on topical use of cosmetics containing  10% of acetyl hexapeptide-8 has indicated that Argireline does not penetrate beyond the uppermost layers of skin. That implies that the underlying layers that lead to the formation of expression lines are affected by Argireline. On the contrary, research revealed that this peptide could penetrate further into the skin if precise formulary measures are followed. Studies showed that increased water content demonstrated more significant penetration and decreased wrinkle depth by 17%. This exemplifies the significance of choosing well-formulated products for your skincare routine. 

If you are looking for a "quick fix" for your wrinkles, this could be your thing. If you are more of a "let's treat this aging thing properly" type, you should look into collagen instead.